NLRP3 and Arrhythmia: Monosodium urate crystals may be phagocytized by immune cells and may activate the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome [43], which can secrete proinflammatory cytokines IL-1a and IL-1b and increases sarcoplasmic reticulum Ca2+ leakage, leading to depressed contractility and arrhythmia [44].