Considering liver fibrosis, incubation with leptin caused indirect upregulation of mir-27a/b in HSCs (hepatic stellate cells), whose activation is a critical step in fibrosis, based on results obtained in vitro and in vivo (C57BL/6J ob/ob mice), via at least three different molecular pathways (β-catenin, Hedgehog, and p38MAPK) [68]. This evidence concerns the gene LEP and Hepatic fibrosis.