Studies on MCC biopsies may jeopardize the inhibitory role of sT on NFκB because significantly higher (p = 0.034) expression of pSer-536 RelA/p65 subunit of NFκB was observed in MCPyV-positive (n = 24) compared to virus-negative (n = 17) MCCs. Here, NFKB1 is linked to Merkel cell skin cancer.