It was reported that celecoxib, the dose of which was equivalent to the one clinically used in human, suppressed tumor growth, local MDSCs infiltration, M2 polarization of tumor-infiltrating macrophages, and IL6 secretion by tumor-infiltrating macrophages in Pten-deficient mouse model under HFD, but not under a normal diet [25]. The gene discussed is IL6; the disease is neoplasm.