PTEN and Familial prostate cancer: In Pten-deficient model mice (<Pb-Cre+;Pten(fl/fl)>) of prostate cancer, the ratio of tumor-infiltrating macrophages expressing CD206 to ones expressing major histocompatibility complex (MHC) class II was increased, and IL6 secreted by tumor-infiltrating macrophages was elevated by HFD [25].