Up to now, low ApoA‐IV levels have been associated with serious conditions such as cardiovascular disorders43, 44, 45 and cancer.46, 47, 48 For instance, ApoA‐IV has been identified as a reliable biomarker in ovarian cancer.49, 50 Moreover, down‐regulated gene expression of ApoA‐IV has been demonstrated in patients with eosinophil‐driven ulcerative colitis51 and blunted ApoA‐IV responses to active lipid absorption after chronic high‐fat diet have been implicated in obesity and metabolic disorders.52, 53 However, the role of apolipoproteins in allergic conditions is still unclear. Here, APOA4 is linked to obesity due to melanocortin 4 receptor deficiency.