The synthesis of CTR is located in hepatopancreas tubules, and mRNA levels of CTR increase after infection with V. anguillarum in F. chinensis. Interestingly, our RNA-seq data and qPCR analyzes also show increased LvCTR transcript levels at 24 hpi suggesting that LvCTR expression is important not only to maintain the normal cellular functions but also in the immune response against Vibrio infections, although additional tests will be needed to determine the exact function of CTR during AHPND in shrimp [88]. The gene discussed is CALCR; the disease is infection.