BIN1 and Alzheimer disease: We found a statistically significant reduction in the percent area of NeuN immunoreactivity in the ipsilateral hippocampus of mice injected with AAV expressing mBin1 shRNA in comparison to the ipsilateral hippocampus of mice injected with AAV expressing scramble shRNA (Fig 1E and 1F), consistent with the hypothesis that BIN1 could be implicated in AD pathology-associated neuronal loss.