APP and Alzheimer disease: Furthermore, a recent study reported that transcriptional profiles from CK-p25 mice and 5XFAD (expressing human APP and PSEN1 transgenes with a total of five AD-linked mutations: the Swedish (K670N/M671L), Florida (I716V), and London (V717I) mutations in APP, and the M146L and L286V mutations in PSEN1) mice show similarities [46].