In the second part of this session, Giannino Del Sal (University of Trieste & IFOM), Wenwei Hu (Rutgers University), Gareth L. Bond (University of Oxford), Jinrong Peng (Zhejiang University), Zhi-Xiong Xiao (Sichuan University), and Peng Jiang (Tsinghua University) spoke about how oncogenic mutant p53 and p53 isoforms affect tumorigenesis, and how common inherited mutations in p53 pathway genes interact with somatic p53 mutations to affect cancer risk and progression. This evidence concerns the gene TP53 and cancer.