Insulin resistance, the hallmark of diabetes, is tightly linked with ECM remodeling and deposition of ECM proteins such as collagens, laminins and fibronectin, predisposing diabetes (Ban & Twigg, 2008; Fukui et al., 1992; A. S. Williams, Kang, & Wasserman, 2015). Here, FN1 is linked to diabetes mellitus.