TNF and type 2 diabetes mellitus: Elevation of IL‐6 during exercise induces an anti‐inflammatory environment by inducing the production of IL‐1ra and IL‐10, and also inhibiting TNF‐α production; subsequently abating the chronic systemic low‐grade inflammation seen in cardiovascular disease, Type 2 diabeters, and muscle wasting (Pedersen & Febbraio, 2008).