CHRNA4 and myasthenia gravis: Myasthenia gravis (MG, acquired, neonatal and congenital) represent the largest group of progressive disorders caused due to impaired signal transmission across the motor end plates due to perturbations to a single (SCN4A mutations, Tsujino et al., 2003) or multiple proteins associated with postsynaptic membrane (nAChR degradation or its associated proteins; rapsyn, agrin, etc.; Engel, 2014).