TLR4 and Insulin resistance: Other mechanisms that contribute to lipid‐induced modulation of insulin resistance (in vitro) have also been identified, such as stimulation of TLR4 (a classical innate immune surface receptor) which switches muscle metabolism to glycolysis (via LPS), inducing insulin resistance (H. Liang, Hussey, Sanchez‐Avila, Tantiwong, & Musi, 2013).