Using the AppNL-F/NL-F mouse model of AD and neuroanatomy combined with electrophysiology, we focused on investigating three subtypes of dendrite-targeting modulatory interneurons in CA1, namely, cholecystokinin (CCK)-expressing, somatostatin (SST)-expressing, and the previously “unexplored”, disinhibitory calretinin (CR) circuitry. This evidence concerns the gene CCK and Alzheimer disease.