GFAP and Alzheimer disease: Whether similar mechanisms exist among the CR cell networks that promote hyperinhibition in AD is unknown, and therefore, we investigated the level of expression colocalization of P2Y1Rs on CR cells and compared the level of P2Y1R colocalization to either GFAP (for reactive astrocytes) or CaMKII-α (for pyramidal cells) from the oldest cohort (after phenotypic changes of the disease), 9–18-month-old AppNL-F/NL-F and wild-type mice (Fig. 7A–C).