It has been suggested that AD-related cortical neurodegeneration is associated with overexcitation of hippocampal activity (Putcha et al. 2011), which is consistent with various in vitro and in vivo models of AD, demonstrating that increased neuronal activity stimulates tau release which further enhances tau pathology (Wu et al. 2016; Yamada et al. 2014), as well as augmentation of Aβ depositions from presynaptic terminals (Yamamoto et al. 2015). Here, MAPT is linked to Alzheimer disease.