In contrast, in the same AD mice, there was an age-dependent increase in the colocalization of Aβ levels with SST- and CCK-expressing cells in the AppNL-F/NL-F mouse model (colocalization of SST with Aβ was 13 ± 4.0%, and CCK with Aβ was 9 ± 3.7%) (Fig. 1H–J), which were significantly different when compared with CR cell colocalization with SST/Aβ and CCK/Aβ at 9–18 months (P < 0.0001 for SST and P < 0.01 for CCK, n = 8 animals for both SST and CCK, two-way ANOVA), suggesting that CCK and SST cells are readily penetrated by Aβ. Here, SST is linked to Alzheimer disease.