Their research also revealed that insulin resistance induced by a high-fat diet was improved extensively in MCP-1 homozygous KO mice compared with WT animals and that acute expression of a dominant-negative mutant of MCP-1 ameliorated insulin resistance in db/db mice, which made it confirmed that MCP-1 played a critical role in adipocyte insulin resistance [45]. This evidence concerns the gene CCL2 and Insulin resistance.