The potential mechanisms of obesity-induced insulin resistance such as kidney mesenchyme development, cellular response to interferon-gamma and cytokine-cytokine receptor interaction and so on were explored with the performance of Gene Set Enrichment Analysis (GSEA), the Gene Ontology (GO) analysis, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis and Protein–Protein Interaction (PPI) network. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.