These findings are in line with a recent multimodality imaging study in which elevated Lp(a) and oxidized phospholipids on apoB were associated with faster disease progression independent of concomitant CAD.15 Furthermore, a secondary analysis of the ASTRONOMER (Aortic Stenosis Progression Observation: Measuring Effects of Rosuvastatin) study,16 which excluded patients with concomitant CAD, demonstrated that elevated Lp(a) and oxidized phospholipids on apoB were associated with faster hemodynamic progression and need for valve replacement. The gene discussed is APOB; the disease is aortic stenosis.