A recent Swedish case‐control study reported that apoB/apolipoprotein A‐I (apoA‐I) ratio and Lp(a) were associated with future AVS surgery in patients with concomitant coronary artery disease (CAD) but not in those with “isolated” AVS.4 These findings suggested that patients with AVS could have different phenotypes, in which risk factors such as atherogenic lipoproteins may or may not play a major role in driving disease progression. Here, APOA1 is linked to coronary artery disorder.