Combination of multiple biomarkers and/or methods has become a trend in cancer diagnosis and screening to improve sensitivity.18 For example, it was reported that the sensitivity for CRC detection was 72.2% and 68.0% respectively, for SEPT9 methylation and fecal immunochemical test (FIT) individually, and the specificity was 81.5% and 97.4%. Here, SEPTIN9 is linked to colorectal carcinoma.