Compared with Epi proColon 2.0, ColoDefense test showed a significant improvement in sensitivities for detecting CRC and AA, likely because the detection of either methylated SEPT9 or methylated SDC2 promoted the LoD of the assay (Table 2) and methylated SDC2 was a more sensitive biomarker in detecting AA.6 This evidence concerns the gene SDC2 and colorectal carcinoma.