AP2A2 (adaptor‐related protein complex 2 (AP2) alpha 2 subunit) positively controls hematopoietic stem cells for asymmetric segregation.25 Interestingly, activation of TP53 also increases asymmetric division in breast cancer stem cells.26 Functioning like TP53 to influence the fate of cancer stem cells, AP2A2 may likewise play a tumor suppression role. This evidence concerns the gene AP2A2 and breast cancer.