SDGS also has three genes, MXD4, BRD2, and AP2A2 that are known to be associated with TP53. As described in Results, the association of MXD4 and BRD2 with TP53 is through direct or indirect interaction with the MYC family,16, 23 which is influenced by TP53 mutation.45 In addition, both AP2A2 and TP53 enhance the asymmetric segregation of cancer stem cells.25 This evidence concerns the gene AP2A2 and cancer.