TERT and intrahepatic cholangiocarcinoma: 3q trisomy, which is highly recurrent in ICC, has been proposed to define transition from cervical dysplasia to invasive carcinoma through effects of the telomerase reverse transcriptase encoding TERT gene.66, 67 The 1q, 5p, 8, 12q, and 14q copy number variations were also detected by genome‐wide SNP analysis (Figure 2E), thus confirming their presence in the tumor.