SOAT1 and neoplasm: Upon cytokine binding to their cognate receptors, JAKs become activated and phosphorylate downstream signal transducer and activator of transcription (STAT) molecules, ultimately leading to nuclear translocation and transcription of various target genes involved in cell cycle regulation, angiogenesis, apoptosis, tumor invasion and metastasis.9 JAK signaling either promotes or suppresses tumorigenesis in a tumor cell intrinsic manner.