Reduced IL6 levels were shown to trigger a switch in the TME toward an antitumoral phenotype.47 TNFα directly endorses tumor progression and metastasis.48 Furthermore, CXCL1 has been reported to facilitate lung cancer cell growth due to the recruitment of MDSCs and tumor associated neutrophils.13, 49 Importantly, all of these factors were also found to be upregulated in K‐rasG12D‐mutated lung alveolar type II (K) cells compared to WT cells or in tumor harboring lungs from KP mice compared to non‐tumorous lungs from KP mice. Here, CXCL1 is linked to neoplasm.