The ChREBP/Mlx heterodimer controls glucose and lipid metabolism through regulating glycolytic (Pklr, Fk, Glut2, Glut4), gluconeogenic (G6pc), and lipogenic (Fasn, Acc1, Scd1, Elovl6) gene expressions [22, 26, 27], suggesting that ChREBP may have an important role in the pathogenesis of metabolic diseases and cancer. This evidence concerns the gene MLXIPL and metabolic disease.