RPL23 is a component of the 60S ribosomal subunit and has been shown to link the oncogenic RAS signaling to p53-mediated tumor suppression.15 T-cell responses to RPL23 also are increased in autoimmune diseases,16 which suggests a role for the RAS/RAF/MAPK pathway in T cells that is currently underexplored. The gene discussed is RAF1; the disease is autoimmune disease.