CD160 is another surface protein tightly expressed on peripheral cytotoxic CD8 T lymphocytes and natural killer cells,31 and soluble CD160 enhances CD8+ T cells, which results in increased interferon-γ, IL-2, and tumor necrosis factor-α secretion as well as cytolysis against tumor cells in vitro and in vivo.32 The gene discussed is TNF; the disease is neoplasm.