In particular, its implication has been shown in systemic lupus erythematosus and T-cell acute lymphoblastic leukemia progression.25-27 WAPL cohesin release factor has been shown to restrict chromatin loop extension.28 Of note, it was part of a microRNA-mRNA network in allogeneic T-cell responses.29 Fermitin family member 3 (FERMT3) is a member of the kindlins that mediates PPI involved in integrin activation. The gene discussed is WAPL; the disease is systemic lupus erythematosus.