Finally, they determined a biomarker panel composed of 4 proteins (IL-2Rα, TNFR1, IL-8 and HGF) that could confirm the diagnosis of GVHD in patients at the onset of clinical symptoms of GVHD and provide prognostic information independent of GVHD severity [70]. This evidence concerns the gene TNFRSF1A and graft versus host disease.