Tanshinone IIA, one of the main compounds of S. miltiorrhiza Bunge, has been shown to inhibit the growth of cancer cells via autophagy and apoptosis, which is related to the Beclin-1/Atg7/Atg12-Atg5 and PI3K/Akt/mTOR pathways [71]. This evidence concerns the gene ATG5 and cancer.