Other genes whose mutational status might be associated with high TMB are KRAS in NSCLCs (due to its link to the smoking signature), MSH2, MSH6, MLH1 in CRCs (due to the relationship between MSI and high TMB) [27, 28] and finally NF1, BRAF, and NRAS in metastatic melanomas [6]. This evidence concerns the gene BRAF and metastatic melanoma.