Positive studies: troponin levels were independently associated with mortality after sepsis in 2 recent meta-analyses.8,9 In a large retrospective study of 598 patients, John J. et al.21 found that elevated cTnI was an independent prognosticator of 28-day mortality in severe sepsis patients (OR: 2.02; 95% CI: 1.15-3.54; p <0.05). The gene discussed is TNNI3; the disease is Sepsis.