In a heterogeneous population of patients with sepsis, severe sepsis, and septic shock, the incidence of elevated troponin ranged from 55% to 85%.12,17,21–23 In studies involving patients with septic shock, there was an incidence of elevated cardiac troponin I ranging from 43% to 80%.16,24,25 In a meta-analysis involving 13 studies and 1227 patients with sepsis, Bessière and colleagues reported a prevalence of 61% of elevated troponin in patients.8 Here, TNNI3 is linked to Sepsis.