PVs in nine of these genes with elevated breast cancer risk were also associated with increased risk for ovarian cancer (BRCA1/2, ATM, BRIP1, RAD51C/D, NBN, TP53, and MSH6), along with MSH2 and PMS2. Odds ratios for ovarian cancer across these 11 genes ranged from 1.91 for ATM to 13.8 for BRCA1. PVs in BRCA2, PALB2, and ATM were significantly associated with increased risk for pancreatic cancer, and PVs in BRCA1, ATM, and CDKN2A were associated with increased risk for melanoma. Here, PMS2 is linked to familial pancreatic carcinoma.