In this study, we systematically evaluated the association of 32 cancer predisposition genes across multiple common phenotypes referred for MGPT with regard to PV frequency, associated cancer risks, and proportion meeting genetic testing criteria for BRCA1/2-related hereditary breast and ovarian cancer and Lynch syndrome to better inform clinical multigene panel selection, as well as medical policy at a broader level. This evidence concerns the gene BRCA1 and Lynch syndrome.