Suppressing FECH expression by siRNA resulted in a significant increase in 5-ALA-induced PpIX in glioma cells (G112, SNB19)28 as well as improved PDT efficacy in four bladder cancer cell lines,31 which suggests that targeting FECH could be a useful adjunct to 5-ALA PDT therapy. The gene discussed is FECH; the disease is urinary bladder cancer.