Previous studies by Kakar S et al.17 and Inamura K et al.15 found BRAF V600E mutation and CIMP-positive status to be more common in SRCC, and proposed that SRCC might be related to the serrated pathway, based on the increased prevalence of BRAF V600Emt and CIIMP-positive status in a majority of serrated polyps.30 However, in metastatic disease, the findings of our study suggest that this association may not be as clear, and suggests the involvement of alternate carcinogenesis pathways. The gene discussed is BRAF; the disease is metastatic neoplasm.