Reciprocal to the known dependency of SMARCA4-deficient cancer cell lines on SMARCA225–27, the majority of SMARCA4-dependent ESCC cell lines (KYSE-270, KYSE-30, KSYE-510 and COLO-680N) displayed low or non-detectable levels of SMARCA2 mRNA and protein expression (Supplementary Fig. S1A). Here, SMARCA2 is linked to esophageal squamous cell carcinoma.