To interrogate the synthetic lethal interaction of SMARCA2 and SMARCA4 in ESCC, we ectopically expressed wild-type, DEXDc- (K755A) and bromodomain-mutant (N1482A) forms of SMARCA2 (SMARCA2ect) in KYSE-510 cells lacking endogenous SMARCA2 expression (Fig. 4A). Here, SMARCA4 is linked to esophageal squamous cell carcinoma.