PTEN and neoplasm: The other over-expressed tumor associated exosomal miRNAs also have interesting biological relevance in MM: miR-222-3p is downregulated in MM and is a negative regulator of CDK1 (p27) and is a PTEN suppressor30; miR-30a-5p (along with miR-222-3p and miR-31-5p), in the same family as miR-30e, is associated with good prognosis when in higher abundance in MM tumors31; and miR-320 family members are suggested as potential biomarkers for malignant pleural mesothelioma32.