TFRC and thalassemia: The level of extramedullary hematopoiesis (ineffective erythropoiesis), indicated by the ratio of erythroid progenitor cells (CD71+Ter119+) outside the bone marrow was also significantly lower in IUGT 12 Weeks animals (p = 0.00075, One Way ANOVA) compared to untreated thalassemia controls and not statistically different from Humanised Non-Thalassemia Controls (p = 0.1, One Way ANOVA)21 (Fig. 2D).