Several soluble factors of tumor microenvironment, secreted by tumor and stromal cells, such as CCL2 (MCP1, monocyte chemoattractant protein-1; C-C motif chemokine ligand 2), CSF1 (colony-stimulating factor 1), CSF2 (colony-stimulating factor 2), VEGFA (vascular endothelial growth factor A), CCL18 (C-C motif chemokine ligand 18), CCL20 (C-C motif chemokine ligand 20), and CXCL12 (C-X-C motif chemokine ligand 12) are doubtless involved in the processes of monocytes recruitment and their polarization at the tumor sites1,15. Here, CXCL12 is linked to neoplasm.