HSPG2 and cancer: Importantly, the reduction of cell invasion in matrices generated by mt-e-CAF KO HSPG2 clones #10 and #18 was more severe than in matrices generated by the mixed mt-e-CAF KO HSPG2 population (Fig. 4f versus Fig. 5a), demonstrating a dose-dependent effect of stromal HSPG2 manipulation on cancer cell invasion.