While GOF mutant p53 in the cancer cell compartment has previously been shown to drive a pro-invasive program4,8,17,18,52,53,57,, our results using long-range conditioning, CAF-based organotypic assays and cell streaming experiments reveal that mt-e-CAFs can induce fl-CC invasion by creating an environment more favorable to invasion, via direct contact and through long-range, paracrine interactions. This evidence concerns the gene TP53 and cancer.