As such, cancer cells harboring a GOF mutant p53 (hereafter referred to as mt-CCs) could co-opt and activate local fibroblasts, while in a spatially distinct region of the tumor tissue, cancer cells with a loss of p53 (herein referred to as fl-CCs), which are less invasive, can recruit and shape different CAF populations45–47(Fig. 2a (i)). This evidence concerns the gene TP53 and neoplasm.