MMP-19 and MMP-20 knockdown not only significantly increased the drug sensitivity to A-1210477 in both Skov3 and Cov362 cells, but also increased the drug sensitivity to Carboplatin in both cell lines, suggesting MMP-19 and MMP-20 high expression are related to at least some kind of anti-cancer drug resistances in OSC patients (Fig. 4). This evidence concerns the gene MMP20 and cancer.