NOS2 and optic neuritis: Interestingly, the polyphenolic compound resveratrol has been shown previously to promote neuroprotection of RGCs by reducing oxidative stress in optic neuritis35,36,41, and has also been reported to inhibit iNOS expression42, suggesting that its neuroprotective effects in optic neuritis may be mediated at least in part by inhibition of iNOS leading to reduced iron accumulation.