SOD1 and amyotrophic lateral sclerosis: Here, we sought to capture global lipidome alterations linked to ALS progression by performing an untargeted mass spectrometry-based lipidomic analysis of motor cortex and spinal cord tissues from ALS asymptomatic (SOD1-G93A 70 days old) and symptomatic (SOD1-G93A 120 days old) rats in comparison to their wild types as controls.