Conversely, VitD treatment, in absence of miR-375 inhibitor, induced MTDH, YAP-1 and c-MYC down-regulation, whereas, in presence of miR-375 inhibitor, VitD was no longer able to down-regulate MTDH, YAP-1 and c-MYC, corroborating the hypothesis that VitD effect is miR-375 dependent also in this HCC cell model (Fig. 6D). This evidence concerns the gene YAP1 and hepatocellular carcinoma.