Indeed, in different cancers, positive correlations between MTDH and YAP-1 expression and mesenchymal biomarkers and, on the contrary, negative correlations between MTDH and YAP-1 expression and epithelial biomarkers have been established59,60; alike, the up-regulation of c-MYC confers a more mesenchymal features in several cancers61. This evidence concerns the gene MYC and cancer.