KDR and pulmonary edema: The FE-induced severe pulmonary edema was significantly attenuated after systemic administration of SU1498 (0.4 mg/kg, I.V.)from 82.1% ± 0.97% to 79.4% ± 0.92%, which suggested that VEGFR-2 mediated the effect of VEGF on FE-induced pulmonary edema (Fig. 1).