NAFLD has a strong genetic component9, with the patatin-like phospholipase domain containing 3 I148M (rs738409, PNPLA3 I148M) and transmembrane 6 superfamily member 2 E167K (rs58542926, TM6SF2 E167K) genetic variants having the largest effect on the susceptibility to the entire spectrum of liver disease9. This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.