Gene expression of cardiac hypertrophy related genes such as MYH6, TNNT2, NPPA, and NPPB was modestly induced in ISO-treated WT hESC-CMs, but was found to be markedly elevated in MLP KO hESC-CMs (Figs. 6f and S6A–G). Here, MYH6 is linked to cardiac hypertrophy.