BECN1 and hydrops fetalis: Because we are unable to study the autophagic flux in these samples, we quantified P62 and beclin-1, other markers of macroautophagy induction and activation and we showed a trend of increase of P62 levels and a significant increase of beclin-1 levels in HF patients compared to NF patients (Fig. 6c) suggesting that macroautophagy is induced but not active in HF patients.