Cell death induction by cotreatment of TNF and MLN4924 was blocked in a cell type-dependent manner by the pan-caspase inhibitor zVAD-fmk or a combination of this compound with the RIPK1 inhibitor necrostatin-1 (nec-1) (Fig. 4b) indicating that MLN4924 sensitizes myeloma cell lines for both apoptosis and necroptosis induction by TNFR1. Here, TNF is linked to plasma cell myeloma.