AURKA and breast cancer: Aur-A has been subsequently reported as an oncogenic factor: (1) it was amplified and/or overexpressed in multiple cancers, including breast, ovarian, and hepatic carcinomas15; (2) forced Aur-A expression resulted in NIH3T3 fibroblast oncogenic transformation and induced aneuploidy in breast cancer cells16; and (3) Aur-A interacts with and modifies the functions of several key cancer-associated molecules, such as the inactivation of BRACA17,18 and p5319,20, leading to tumorigenesis and tumor progression.