CASP3 and neoplasm: Importantly, our IHC staining of tumor tissues revealed that compared with MLN8237 or rapamycin single-agent treatment, combination of the two agents more significantly inhibited cell growth (decrease of Ki-67 and increase of p21) and induced apoptosis (increase of cleavage caspase-3) (MLN8237 or rapamycin vs. MLN8237 + rapamycin: P < 0.01; Fig. 5d).