The present study suggested the potential role of the three commonly studied hormones in relation to PPD, and revealed neuroprotective and antidepressant effects of the combined administration of E2, P, and MMI, which reduced TH and increased estrogen and progestogen via CREB-BDNF system, in the progression of PPD. Here, CREB1 is linked to progressive pseudorheumatoid arthropathy of childhood.