One of the high-confidence AP-MS-identified eukaryotic proteins (significant in each Inc-APEX2 data set [BFDR = 0]), leucine-rich repeat in flightless-interacting protein 1 (LRRF1), has been reported to be involved in activating a type I interferon response (51, –, 55), which plays a role in host cell clearance of intracellular bacteria during infection and the development of adaptive immunity (56). This evidence concerns the gene LRRFIP1 and infection.