In this study, although IL-2 increased in CSCC cases, the Th1/Th2 ratio was lowest in CSCC cases, therefore the IL-2/IL-10 drift could better reflect the immune state of the body, and it indicates that the imbalance of T cell immune response was probably more and more obvious with the progression of the disease, causing Th1 to drift to Th2 in the body, and decrease cellular immune function. Here, IL10 is linked to skin squamous cell carcinoma.