The aim of the present study was to investigate the relationship between the BDNF Val66Met polymorphism, obesity, and thrombosis, by analyzing the adipose tissue profile in BDNFMet/Met mice, and to evaluate the ability of PE to affect adipose tissue and reduce the prothrombotic phenotype in BDNF Val66Met knock-in mice. Here, BDNF is linked to obesity due to melanocortin 4 receptor deficiency.