TNF and obesity due to melanocortin 4 receptor deficiency: The adipose tissue accumulation found in BDNFMet/Met mice was accompanied by a higher expression of the M1 proinflammatory marker CD80, of the monocyte chemoattractant protein-1 (Mcp-1) and of the mediators of inflammation such as Pai-1, Tnf-alpha, and Il-6, which is in line with the well-established paradigm that overweight and obesity are related to adipose tissue inflammation [67].