FMR1 and autism: Although fragile X syndrome (FXS) is caused by a hypermethylated full mutation (FM) expansion with ≥200 cytosine-guanine-guanine (CGG) repeats, and a decrease in <i>FMR1</i> mRNA and its protein (FMRP), incomplete silencing has been associated with more severe autism features in FXS males.