Recently, in a cohort of autopsy-confirmed neurodegenerative disease cases, researchers investigated whether changes in DAT images reflected loss of DAT, because of cell death or neurodegenerative pathology, by examining the influence of nigral neuronal loss as well as nigral (α-syn, tau) and striatal (α-syn, tau, amyloid-β) pathology on striatal uptake in 4 cases of Alzheimer’s disease (AD), 7 cases of dementia with Lewy bodies (DLB), and 12 Parkinson’s disease dementia (PDD) cases. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.