To complicate matters further, in some degenerative parkinsonisms, such as corticobasal degeneration (CBD) [32] and dementia with Lewy body (DLB) [33,34], in which nigrostriatal dopaminergic dysfunction is usually present, initial DAT-SCANs can be normal, and patients may develop later alterations of DAT imaging in the course of the disease [34,35,36,37,38] (Figure 1). The gene discussed is SLC6A3; the disease is corticobasal degeneration disorder.