Furthermore, we found that the PD-1 rs2227982 was associated with an increased risk of cancer in hospital based studies (OR = 1.22, 95% CI = 1.06–1.40, p = 0.006, CT vs. CC; OR = 1.20, 95% CI = 1.05–1.37, p = 0.008, CT+TT vs. CC). Here, PDCD1 is linked to cancer.