We investigated the distribution of the 1, 2, 3, 4, 5.1, 5.2, 5.3, 7.1, 7.2, 8, 9, 11, 12, 13.1, 13.2, 13.6, 14, 16, 17, 18, 20, 21.3, 22 and 23 Vβ receptor T-cell repertoire families of the CD4+ TN, TEM, TE and TCM lymphocytes from MTX responder and non-responder recently diagnosed RA patients at baseline and after 6 months of treatment (Figure 6). Here, CD4 is linked to rheumatoid arthritis.