To evaluate predictive models integrating IHC analysis, we used IHC analysis of six proteins (i.e., Ki67, EGFR, PTEN, CD44, p53, vimentin) which include proteins routinely analyzed in current clinical practice, using a tissue microarray constructed for our internal MUHC cohort of GBM IDH1 wild-type patients (n = 129). This evidence concerns the gene EGFR and glioblastoma.