We used the Wilcoxon rank-sum test to compare the distribution of radiomic feature values across gene mutation or methylation status (e.g., EGFR, MGMT, etc.)and Kruskal–Wallis test to compare between radiomic features values across molecular subtypes (i.e., classical, mesenchymal, proneural, and neural) of IDH1 wild-type GBM patients (Figure S1). The gene discussed is MGMT; the disease is glioblastoma.