ALS2 and frontotemporal dementia: Of note, this variant is fivegenes, i.e., SORL1, FUS, LRRK2, ALS2 and ABCA7. These data are in line with our findings in early onset dementia patients and with the recently reported evidence, suggesting that sporadic forms of FTD could represent a polygenic disorder where multiple pleiotropic loci contribute to disease risk [32,87].